Functions of Growth Hormone

Growth hormone is secreted by the pituitary gland during REM sleep. Its functions are

  • Maintenance of bones, joints, muscle and connective tissue;
  • In frail elderly, it will improve lean muscle mass, bone density and improve stamina
  • It has significant effects on the brain:- receptors are located in the hippocampus – which is an important site for short term and working memory: supplementation in adults suffering from growth hormone deficiency improves mood, alertness, motivation, , memory, and general cognitive function
  • It has been shown to reverse osteoporosis and speed recovery from hip fracture;
  • It is also beneficial in the treatment of refractory heart failure, and has been shown to improve arteriosclerosis and decrease LDL cholesterol, triglycerides and CRP ( an index of inflammation associated with increased of heart disease);
  • It is important for immune function –and will reverse age-related decline in the production of  T and B–cell lymphocytes
  • It acts synergistically with testosterone and DHEA in improving lean muscle mass, decreasing abdominal fat up to 50%, and increasing VO2 max (aerobic capacity)

Growth hormone production declines with age from the mid 30”s – reaching about 50% maximum by age 50, and declining by 50% every 7 years after that. Growth hormone deficiency is the major factor behind frailty syndrome (frail older people with brittle bones and mobility problems)

Diagnosis of Adult Growth Hormone deficiency
Practical issues with Recombinant HGH Replacement therapy
Alternatives to HGH Replacement Therapy